According to World Health Organisation HIV still continues to be a major global public health issue, having claimed more than 34 million lives so far. And almost 16 million people were under treatment for AIDS in 2015. To improve the quality of life of HIV positive patients intense research was conducted by Dr. Santhosh Selvam from 2010 which led to various version of antiviral formulations and of which the optimised version of anti-HIV with literally no diet restriction and side effects was achieved in the year 2013.

The dosage regimen of the anti-HIV medicine will be two capsules twice a day after food. Patient can experience better improvements from fifteenth day of treatment and there will reduced viral load from the first month.

BEFORE TREATMENT

AFTER TREATMENT

Turmeric, a yellow spice used in Indian dishes has been found to possess activity against HIV and cancer. Earlier studies conducted over it had confirmed the anti-microbial, anti-tumour and anti-inflammatory properties of turmeric’s main component, curcumin. Curcumin, a relatively non-toxic natural product isolated from Curcuma longa, is a modest inhibitor of the HIV-1 (IC50 = 100 microM) and HIV-2 (IC50 = 250 microM) proteases.

In laboratory studies it was found that curcumin was able to unbind the virus from the human protein. And according to a community clinical study conducted by the AIDS research in Los Angeles it was found that curcumin was able to  reduce the p24 in seven days when taken in a dosage of 2.5 gm per day.

According to Mayo Clinic, HIV infection initially begins with flu like symptoms within two weeks to three months. It is accompanied by following symptoms:

• sore throat
• mouth or genital ulcers
• head aches
• nausea and vomiting
• night sweats
• rash on the arms, legs,face or belly
• rapid weight loss
• blurred or distorted vision
• fever, chills and night sweats 

The chronic and life long infection of HIV is due to its ability to stay hidden within infected blood cells. These cellular “reservoirs ” holds the genetic code of HIV. Thus they remain invisible to our body’s immune response and also are not sensitive to anti HIV drugs.

Most of the HIV therapies available for the treatment of AIDS prevents it by dramatically reducing, but not eliminating the HIV infection. Although a HIV patient undergoes a long term antiviral therapy still the reservoir of HIV infected cells continue to exist there by increasing the risk of developing non-AIDS illness like accelerated heart, bone, or kidney disease in the individuals.

The advanced antiviral therapy adopted prevent the AIDS and suppress HIV replication to nearly undetectable levels in over 90% of treatment-naive patients. However if the treatment is interrupted the viral replication again starts back, which makes the patient to continue medicine throughout the life time.  

Therefore novel strategies are required to safely kill the HIV infected cells and eliminate the HIV reservoir. The HIV has the ability to establish latency in a subset of infected CD4 T cells and limits the ability of antiviral therapy to reduce the reservoir of HIV.

According to a study conducted at John Hopkins University School of Medicine it has been found that the proviral DNA of HIV has been detected in multiple CD4 T cells immune cells which are permissive of HIV infection. Additionally, there is evidence that persistently infected cells capable of expressing low but detectable levels of HIV protein exist. Thereby acts as a reservoir of HIV.